RT Journal Article
SR Electronic
T1 Radiobiologic Principles in Radionuclide Therapy
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 4S
OP 12S
VO 46
IS 1 suppl
A1 Amin I. Kassis
A1 S. James Adelstein
YR 2005
UL http://jnm.snmjournals.org/content/46/1_suppl/4S.abstract
AB Although the general radiobiologic principles underlying external beam therapy and radionuclide therapy are the same, there are significant differences in the radiobiologic effects observed in mammalian cells. External beam and brachytherapy emissions are composed of photons, whereas radiations of interest in radionuclide therapy are particulate. The special features that characterize the biologic effects consequent to the traversal of charged particles through mammalian cells are explored with respect to DNA lesions and cellular responses. Information about the ways in which these radionuclides are used to treat cancers in experimental models are highlighted.