RT Journal Article
SR Electronic
T1 Simultaneous Assessment of Gastric Accommodation and Emptying: Studies with Liquid and Solid Meals
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1155
OP 1160
VO 45
IS 7
A1 Hrair P. Simonian
A1 Alan H. Maurer
A1 Linda C. Knight
A1 Steve Kantor
A1 Despina Kontos
A1 Vasileios Megalooikonomou
A1 Robert S. Fisher
A1 Henry P. Parkman
YR 2004
UL http://jnm.snmjournals.org/content/45/7/1155.abstract
AB The aim of this study was to develop a scintigraphic test to measure gastric emptying and accommodation simultaneously. Methods: Gastric emptying and accommodation were measured in healthy subjects. To determine gastric accommodation, the stomach was imaged with SPECT 20 min after intravenous administration of 185 MBq (5 mCi) 99mTc-pertechnetate. After ingestion of 11 MBq (300 μCi) 111In-diethylenetriaminepentaacertic acid in a liquid nutrient drink or an 111In-oxine–labeled egg sandwich, dual-isotope imaging assessed SPECT gastric dimensions and gastric emptying every 20 min up to 240 min. Gastric accommodation was calculated as the percentage change in planar (2-dimensional) gastric cross-sectional area (CSA) using a left anterior oblique planar projection and the percentage change in total SPECT gastric voxel counts (3-dimensional) compared with the baseline image. Results: With the liquid nutrient drink (9 subjects), maximal mean CSA (158% ± 12% of baseline; P < 0.05) occurred 40 min after meal ingestion, when only 69% ± 3% of the radiolabeled liquid nutrient drink remained in the stomach. At 120 min, mean CSA was 125% ± 8% of baseline, but only 35% ± 3% of the liquid nutrient drink remained in the stomach. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred 20 min after meal ingestion (189% ± 25% of baseline). With the solid egg meal (10 subjects), maximal total CSA (159% ± 13% of baseline) occurred immediately after meal ingestion; total CSA remained significantly increased above baseline for the first 3 h after ingestion of the egg meal, despite only 12% ± 4% gastric retention at 3 h. Using SPECT to measure 3-dimensional volumes, maximal gastric volume occurred immediately after the meal (184% ± 19% of baseline). Conclusion: This method permits simultaneous measurement of gastric emptying and accommodation. In healthy subjects, the gastric accommodation response is prolonged and persists despite nearly complete emptying of a liquid or solid meal.