TY - JOUR T1 - Gated SPECT Evaluation of the Relationship Between Admission Troponin I, Myocardial Salvage, and Functional Recovery in Acute Myocardial Infarction Treated by Abciximab and Early Primary Angioplasty JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 739 LP - 744 VL - 45 IS - 5 AU - Mario Leoncini AU - Francesco Bellandi AU - Roberto Sciagrà AU - Mauro Maioli AU - Anna Toso AU - Angela Coppola AU - Stelvio Sestini AU - Alberto Mennuti AU - Roberto Piero Dabizzi AU - Alberto Pupi Y1 - 2004/05/01 UR - http://jnm.snmjournals.org/content/45/5/739.abstract N2 - Using gated SPECT, we evaluated the relationship between admission troponin I, risk area, and myocardial salvage in patients with a first myocardial infarction treated with abciximab and primary percutaneous coronary intervention within 6 h. Methods: In 43 patients, 99mTc-sestamibi was injected before primary percutaneous coronary intervention. Gated SPECT was acquired immediately thereafter and was repeated 7 and 30 d later. The initial risk area and subsequent infarct size were expressed as a percentage of the left ventricle; salvage index was the ratio between salvaged myocardium and initial risk area; left ventricular ejection fraction was calculated using the quantitative gated SPECT software. Results: On admission, 20 patients showed elevated troponin I and had a larger risk area (P < 0.03) than did the group with normal troponin I. Infarct size at 30 d (15% ± 12% vs. 13% ± 13%) and salvage index (0.63 ± 0.27 vs. 0.60 ± 0.28) were not significantly different between the 2 groups. Ejection fraction was lower in the group with high troponin I on admission (36% ± 10% vs. 41% ± 11%, P < 0.05) and at 7 d (41% ± 11% vs. 48 ± 10, P < 0.03). At 30 d, improvement was greater in the group with high troponin I, and ejection fraction became comparable. Conclusion: Patients with high troponin I on admission have a larger initial risk area, but if they undergo primary percutaneous coronary intervention within 6 h and are treated with abciximab, myocardial salvage and functional recovery are similar to those observed in patients with normal troponin I, and no unfavorable relationship between high troponin I values on admission and myocardial salvage is registered. ER -