@article {Leoncini739, author = {Mario Leoncini and Francesco Bellandi and Roberto Sciagr{\`a} and Mauro Maioli and Anna Toso and Angela Coppola and Stelvio Sestini and Alberto Mennuti and Roberto Piero Dabizzi and Alberto Pupi}, title = {Gated SPECT Evaluation of the Relationship Between Admission Troponin I, Myocardial Salvage, and Functional Recovery in Acute Myocardial Infarction Treated by Abciximab and Early Primary Angioplasty}, volume = {45}, number = {5}, pages = {739--744}, year = {2004}, publisher = {Society of Nuclear Medicine}, abstract = {Using gated SPECT, we evaluated the relationship between admission troponin I, risk area, and myocardial salvage in patients with a first myocardial infarction treated with abciximab and primary percutaneous coronary intervention within 6 h. Methods: In 43 patients, 99mTc-sestamibi was injected before primary percutaneous coronary intervention. Gated SPECT was acquired immediately thereafter and was repeated 7 and 30 d later. The initial risk area and subsequent infarct size were expressed as a percentage of the left ventricle; salvage index was the ratio between salvaged myocardium and initial risk area; left ventricular ejection fraction was calculated using the quantitative gated SPECT software. Results: On admission, 20 patients showed elevated troponin I and had a larger risk area (P \< 0.03) than did the group with normal troponin I. Infarct size at 30 d (15\% {\textpm} 12\% vs. 13\% {\textpm} 13\%) and salvage index (0.63 {\textpm} 0.27 vs. 0.60 {\textpm} 0.28) were not significantly different between the 2 groups. Ejection fraction was lower in the group with high troponin I on admission (36\% {\textpm} 10\% vs. 41\% {\textpm} 11\%, P \< 0.05) and at 7 d (41\% {\textpm} 11\% vs. 48 {\textpm} 10, P \< 0.03). At 30 d, improvement was greater in the group with high troponin I, and ejection fraction became comparable. Conclusion: Patients with high troponin I on admission have a larger initial risk area, but if they undergo primary percutaneous coronary intervention within 6 h and are treated with abciximab, myocardial salvage and functional recovery are similar to those observed in patients with normal troponin I, and no unfavorable relationship between high troponin I values on admission and myocardial salvage is registered.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/45/5/739}, eprint = {https://jnm.snmjournals.org/content/45/5/739.full.pdf}, journal = {Journal of Nuclear Medicine} }