TY - JOUR T1 - In Vitro Proton Magnetic Resonance Spectroscopic Lactate and Choline Measurements, <sup>18</sup>F-FDG Uptake, and Prognosis in Patients with Lung Adenocarcinoma JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1334 LP - 1339 VL - 45 IS - 8 AU - JianFei Guo AU - Kotaro Higashi AU - Hajime Yokota AU - Yosinobu Nagao AU - Yoshimichi Ueda AU - Yuko Kodama AU - Manabu Oguchi AU - Suzuka Taki AU - Hisao Tonami AU - Itaru Yamamoto Y1 - 2004/08/01 UR - http://jnm.snmjournals.org/content/45/8/1334.abstract N2 - It has been reported that 18F-FDG uptake, lactate concentration, and choline concentration are good indicators of malignant grade in several different kinds of tumors. In this study, we investigated the correlation between 18F-FDG uptake in 18F-FDG PET imaging, lactate concentration and choline concentration measured by in vitro 1H magnetic resonance spectroscopy (MRS), and survival probabilities in human lung adenocarcinoma. Methods: Nineteen patients with lung adenocarcinoma underwent 18F-FDG PET before surgery. The 1H MRS spectra were obtained in vitro from methanol–chloroform–water extracts of lung adenocarcinomas and normal lungs. The ratios of the lactate (Rlac) or choline (Rcho) concentration of lung adenocarcinoma to normal lung from the same patient were correlated with the mean standardized uptake value (SUV). The Kaplan–Meier life table method was used to analyze the relationship between 18F-FDG uptake, Rlac, Rcho, and patient survival probabilities. Results: There was no significant correlation between mean SUV and Rlac or Rcho in patients with lung adenocarcinoma. An SUV &gt; 5 means poorer survival probabilities in patients with lung adenocarcinoma (P = 0.004). A higher Rlac probably indicates a trend for patients with lung adenocarcinoma to have poorer survival probabilities; however, Rcho is not an indicator of survival probability. 18F-FDG uptake significantly correlated with cell differentiation (P = 0.007), whereas Rlac and Rcho had no correlation with it. Conclusion: No significant correlation was found between SUV and Rlac or Rcho in patients with lung adenocarcinoma. Compared with Rlac and Rcho measured by in vitro MRS, 18F-FDG uptake is a better indicator of prognosis in patients with lung adenocarcinoma. ER -