PT  - JOURNAL ARTICLE
AU  - Watanabe, Naoto
AU  - Kanegane, Hirokazu
AU  - Kinuya, Seigo
AU  - Shuke, Noriyuki
AU  - Yokoyama, Kunihiko
AU  - Kato, Hiroshi
AU  - Tomizawa, Gakuto
AU  - Shimizu, Masashi
AU  - Funada, Hisashi
AU  - Seto, Hikaru
TI  - The Radiotoxicity of <sup>131</sup>I Therapy of Thyroid Cancer: Assessment by Micronucleus Assay of B Lymphocytes
DP  - 2004 Apr 01
TA  - Journal of Nuclear Medicine
PG  - 608--611
VI  - 45
IP  - 4
4099  - http://jnm.snmjournals.org/content/45/4/608.short
4100  - http://jnm.snmjournals.org/content/45/4/608.full
SO  - J Nucl Med2004 Apr 01; 45
AB  - We investigated cytologic radiation damage in thyroid cancer after 131I therapy using micronucleus assay (MNA) of B lymphocytes exclusively, as opposed to our previous study in which MNA of all lymphocyte subsets was used. Methods: We studied 22 thyroid cancer patients treated with 3.7 GBq of 131I. Peripheral lymphocytes were harvested, and B lymphocytes were isolated by an immunomagnetic method and assayed for the frequency of micronuclei. Results: The frequency of micronuclei among B cells after 131I therapy was significantly increased relative to that in untreated control subjects, and the 131I-induced increase in micronuclei frequency among B cells was significantly greater than that among all lymphocytes. Conclusion: Compared with the MNA of all lymphocytes, the MNA among specifically B cells may more sensitively detect cytologic radiation damage associated with 131I therapy of thyroid cancer.