TY - JOUR T1 - The Radiotoxicity of <sup>131</sup>I Therapy of Thyroid Cancer: Assessment by Micronucleus Assay of B Lymphocytes JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 608 LP - 611 VL - 45 IS - 4 AU - Naoto Watanabe AU - Hirokazu Kanegane AU - Seigo Kinuya AU - Noriyuki Shuke AU - Kunihiko Yokoyama AU - Hiroshi Kato AU - Gakuto Tomizawa AU - Masashi Shimizu AU - Hisashi Funada AU - Hikaru Seto Y1 - 2004/04/01 UR - http://jnm.snmjournals.org/content/45/4/608.abstract N2 - We investigated cytologic radiation damage in thyroid cancer after 131I therapy using micronucleus assay (MNA) of B lymphocytes exclusively, as opposed to our previous study in which MNA of all lymphocyte subsets was used. Methods: We studied 22 thyroid cancer patients treated with 3.7 GBq of 131I. Peripheral lymphocytes were harvested, and B lymphocytes were isolated by an immunomagnetic method and assayed for the frequency of micronuclei. Results: The frequency of micronuclei among B cells after 131I therapy was significantly increased relative to that in untreated control subjects, and the 131I-induced increase in micronuclei frequency among B cells was significantly greater than that among all lymphocytes. Conclusion: Compared with the MNA of all lymphocytes, the MNA among specifically B cells may more sensitively detect cytologic radiation damage associated with 131I therapy of thyroid cancer. ER -