RT Journal Article SR Electronic T1 99mTc-Stannous Colloid White Cell Scintigraphy in Childhood Inflammatory Bowel Disease JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 261 OP 265 VO 45 IS 2 A1 Peacock, Kenneth A1 Porn, Ute A1 Howman-Giles, Robert A1 O’Loughlin, Edward A1 Uren, Roger A1 Gaskin, Kevin A1 Dorney, Stuart A1 Kamath, Ramanand YR 2004 UL http://jnm.snmjournals.org/content/45/2/261.abstract AB 99mTc-Labeled white cell scintigraphy (WCS) has been used for the investigation of inflammatory bowel disease (IBD) in adults, but data on children are limited. The most common agent used is 99m Tc-hexamethylpropyleneamine oxime (HMPAO); however, this agent has limitations. In a retrospective study, we assessed the use of 99mTc-stannous colloid WCS for the initial evaluation of children with suspected IBD. Methods: Diagnostic, endoscopic, and contrast radiography results were retrospectively collected from the medical records. Two experienced nuclear physicians unaware of the patient data interpreted the WCS results, with agreement reached by consensus. Statistical analysis was performed on the ability of WCS to detect active disease and localize it topographically and on a comparison of diagnostic methods, using a combination of clinical features and endoscopy as the reference standard. Results: Between 1996 and 1999, 64 patients (35 male and 29 female; mean age, 12.5 y; age range, 2–19 y) had WCS performed, with IBD subsequently diagnosed in 34 patients. 99mTc-Stannous colloid WCS had an 88% sensitivity, 90% specificity, and 8.8 likelihood ratio for initial investigation of IBD. Agreement was poor for topographic localization of disease. Small-bowel series had a 75% sensitivity, 50% specificity, and 1.5 likelihood ratio for detecting endoscopic disease of the terminal ileum and proximal colon. Conclusion: Our results confirm that WCS is a useful imaging technique for the initial evaluation of patients with suspected IBD. 99mTc-Stannous colloid had results at least comparable to those of other WCS agents, and in children, 99mTc-stannous colloid WCS should be preferred in view of lower cost, shorter preparation time, and the smaller blood volumes required.