RT Journal Article
SR Electronic
T1 Kinetic Analysis of <sup>18</sup>F-Fluorodihydrorotenone as a Deposited Myocardial Flow Tracer: Comparison to <sup>201</sup>Tl
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1950
OP 1959
VO 45
IS 11
A1 Marshall, Robert C.
A1 Powers-Risius, Patricia
A1 Reutter, Bryan W.
A1 O’Neil, James P.
A1 La Belle, Michael
A1 Huesman, Ronald H.
A1 VanBrocklin, Henry F.
YR 2004
UL http://jnm.snmjournals.org/content/45/11/1950.abstract
AB The goals of this investigation were to assess the accuracy of 18F-fluorodihydrorotenone (18F-FDHR) as a new deposited myocardial flow tracer and to compare the results to those for 201Tl. Methods: The kinetics of these flow tracers in 22 isolated, erythrocyte- and albumin-perfused rabbit hearts were evaluated over a flow range encountered in patients. The 2 flow tracers plus a vascular reference tracer (131I-albumin) were introduced as a bolus through a port just above the aortic cannula. Myocardial extraction, retention, washout, and uptake parameters were computed from the venous outflow curves with the multiple-indicator dilution technique and spectral analysis. Results: The mean ± SD initial extraction fractions for 18F-FDHR (0.85 ± 0.07) and 201Tl (0.87 ± 0.05) were not significantly different, although the initial extraction fraction for 18F-FDHR declined with flow (P &lt; 0.0001), whereas the initial extraction fraction for 201Tl did not. The washout of 201Tl was faster (P &lt; 0.001) and more affected by flow (P &lt; 0.05) than was the washout of 18F-FDHR. Except for the initial extraction fraction, 18F-FDHR retention was higher (P &lt; 0.001) and less affected by flow (P &lt; 0.05) than was 201Tl retention. Reflecting its superior retention, the net uptake of 18F-FDHR was better correlated with flow than was that of 201Tl at both 1 and 15 min after tracer introduction (P &lt; 0.0001 for both comparisons). Conclusion: The superior correlation of 18F-FDHR uptake with flow indicates that it is a better flow tracer than 201Tl in the isolated rabbit heart. Compared with the other currently available positron-emitting flow tracers (82Rb, 13N-ammonia, and 15O-water), 18F-FDHR has the potential of providing excellent image resolution without the need for an on-site cyclotron.