RT Journal Article
SR Electronic
T1 Educational Level Influences Regional Cerebral Blood Flow in Patients with Alzheimer’s Disease
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1860
OP 1863
VO 45
IS 11
A1 Nan-Tsing Chiu
A1 Bi-Fang Lee
A1 Sigmund Hsiao
A1 Ming-Chyi Pai
YR 2004
UL http://jnm.snmjournals.org/content/45/11/1860.abstract
AB We tested the hypothesis that educational level influences regional cerebral blood flow (rCBF) in Alzheimer’s disease (AD) patients. Methods: The severity of AD was measured with the Cognitive Ability Screening Instrument (age and education adjusted). rCBF was assessed using 99mTc-hexamethylpropyleneamine oxime brain SPECT; differences in rCBF between groups with different educational levels were determined using statistical parametric mapping (SPM). Results: In matched low-education (≤6 y; n = 29) and high-education (>6 y; n = 29) groups, SPM revealed 2 statistically significant clusters of voxels with higher rCBF in the high-education group: one in the left lateral inferior, middle, and superior temporal gyrus; another in the left medial temporal area to the left inferior frontal gyrus. Conclusion: We provide biologic evidence that education may lead to relatively higher rCBF in specific areas in AD patients, which may explain the effects of education on clinical manifestations of AD.