TY - JOUR T1 - Radio-Tympano-Sinu-Orthesis with <sup>186</sup>Re-Colloid: A New Treatment Modality for Chronic Otitis Media and Paranasal Mucositis JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 559 LP - 564 VL - 44 IS - 4 AU - Willm U. Kampen AU - Godber S. Godbersen AU - Norbert Czech AU - Otto F. Besch AU - Winfried Brenner AU - Eberhard Henze Y1 - 2003/04/01 UR - http://jnm.snmjournals.org/content/44/4/559.abstract N2 - This preliminary treatment trial was performed to evaluate the safety and clinical efficacy of intracavitary therapy with 186Re-colloid in patients with recurrent otitis media and paranasal sinusitis, resistant to pharmacotherapy and surgical treatment. Methods: Thirty-nine applications of 5–35 MBq 186Re-colloid into the tympanon and the paranasal sinuses were performed in 6 patients. Biodistribution and biokinetics were studied by gamma-camera imaging. Clinical success was documented 6–20 mo after therapy by each patient’s self-evaluation and by rhinootologic follow-up, using a 4-step score. Results: No harmful side effects were seen. There was good-to-excellent clinical improvement with a score of +1.44 ± 0.5 by each patient’s self-evaluation and by physicians scoring of +0.81 ± 0.9 with only negligible extracranial tracer deposition. Conclusion: This novel treatment option using intracavitary application of 186Re-colloid in chronic otitis media and sinusitis is safe and effective. The term “radio-tympano-sinu-orthesis” might be proposed analogously to the well-known radiosynoviorthesis. ER -