RT Journal Article SR Electronic T1 Clinical Usefulness of 18F-FDG PET in Nasopharyngeal Carcinoma Patients with Questionable MRI Findings for Recurrence JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1669 OP 1676 VO 45 IS 10 A1 Ng Shu-Hang A1 Joseph Chang Tung-Chieh A1 Chan Sheng-Chieh A1 Ko Sheung-Fat A1 Wang Hung-Ming A1 Liao Chun-Ta A1 Chang Yu-Chen A1 Wuu-Jyh Lin A1 Fu Ying-Kai A1 Yen Tzu-Chen YR 2004 UL http://jnm.snmjournals.org/content/45/10/1669.abstract AB It has been reported that 18F-FDG PET is highly sensitive for the detection of recurrent head-and-neck cancer. The objective of our prospective study was to validate the ability of this technique to detect the presence of tumors in primary, nodal, and distant sites as well as to assess its overall clinical usefulness in patients with questionable MRI findings for residual or recurrent nasopharyngeal carcinoma (NPC). Methods: From January 2002 to October 2003, a group of 37 NPC patients whose postradiation follow-up MRI examination showed questionable residual or recurrent disease was assessed with 18F-FDG PET. 18F-FDG PET was interpreted visually. Disease at primary, nodal, and distant sites was assessed. The final diagnosis was confirmed histopathologically or with clinical and imaging follow-up of at least 6 mo. Results: Our results showed that the sensitivity and specificity of 18F-FDG PET for the detection of recurrent NPC were 91.6% and 76.0%, respectively, at the primary site; 90.0% and 88.9%, respectively, at nodal sites; and 100% and 90.6%, respectively, at distant sites. The overall sensitivity and specificity were 89.5% and 55.6%, respectively. Among the 37 patients, 18F-FDG PET added significant information to the MRI findings in 18, including offering true-negative findings in 10, revealing unexpected small metastatic adenopathy in 3, and disclosing distant metastatic foci in 5. Conclusion: 18F-FDG PET is highly sensitive and moderately specific for the detection of recurrent NPC in patients with questionable MRI findings. Overall, 18F-FDG PET appears to add significant information to MRI findings in about half of the NPC patients whose MRI examination shows questionable tumor recurrence.