RT Journal Article
SR Electronic
T1 The Role of Nuclear Medicine in the Prediction and Detection of Radiation-Associated Normal Pulmonary and Cardiac Damage
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1531
OP 1539
VO 44
IS 9
A1 Goethals, Ingeborg
A1 Dierckx, Rudi
A1 De Meerleer, Gert
A1 De Sutter, Johan
A1 De Winter, Olivier
A1 De Neve, Wilfried
A1 Van de Wiele, Christophe
YR 2003
UL http://jnm.snmjournals.org/content/44/9/1531.abstract
AB Dose–effect calculations used in the planning of modern radiotherapy (RT) involving normal lung or cardiac tissue rely on structural imaging techniques, such as CT, as the basis for measuring and predicting dose–response. However, more accurate methods for predicting dose–response may result if information on the locoregional functional status of the irradiated organ(s) is included in the computational model. For RT cases that involve delivering dose to the lung and heart, this may be achieved by the assessment of tomographic scintigraphies of lung perfusion (Q) and ventilation (V) and scintigraphic imaging of myocardial perfusion and function, respectively.