PT - JOURNAL ARTICLE AU - Ingeborg Goethals AU - Rudi Dierckx AU - Gert De Meerleer AU - Johan De Sutter AU - Olivier De Winter AU - Wilfried De Neve AU - Christophe Van de Wiele TI - The Role of Nuclear Medicine in the Prediction and Detection of Radiation-Associated Normal Pulmonary and Cardiac Damage DP - 2003 Sep 01 TA - Journal of Nuclear Medicine PG - 1531--1539 VI - 44 IP - 9 4099 - http://jnm.snmjournals.org/content/44/9/1531.short 4100 - http://jnm.snmjournals.org/content/44/9/1531.full SO - J Nucl Med2003 Sep 01; 44 AB - Dose–effect calculations used in the planning of modern radiotherapy (RT) involving normal lung or cardiac tissue rely on structural imaging techniques, such as CT, as the basis for measuring and predicting dose–response. However, more accurate methods for predicting dose–response may result if information on the locoregional functional status of the irradiated organ(s) is included in the computational model. For RT cases that involve delivering dose to the lung and heart, this may be achieved by the assessment of tomographic scintigraphies of lung perfusion (Q) and ventilation (V) and scintigraphic imaging of myocardial perfusion and function, respectively.