PT - JOURNAL ARTICLE AU - Koyama, Koichi AU - Okamura, Terue AU - Kawabe, Joji AU - Ozawa, Nozomi AU - Torii, Kenzi AU - Umesaki, Naohiko AU - Miyama, Masato AU - Ochi, Hironobu AU - Yamada, Ryusaku TI - Evaluation of <sup>18</sup>F-FDG PET with Bladder Irrigation in Patients with Uterine and Ovarian Tumors DP - 2003 Mar 01 TA - Journal of Nuclear Medicine PG - 353--358 VI - 44 IP - 3 4099 - http://jnm.snmjournals.org/content/44/3/353.short 4100 - http://jnm.snmjournals.org/content/44/3/353.full SO - J Nucl Med2003 Mar 01; 44 AB - The purpose of this study was to evaluate PET using 18F-FDG for gynecologic lesions with continuous bladder irrigation to eliminate artifacts from the 18F-FDG activity in the bladder. Methods: Forty-one patients were studied. They had 23 cervical uterine lesions (15 cases of cancer, 5 recurrences, 3 nonrecurrences); 8 cases of uterine corpus cancer, including 2 recurrences; and 10 ovarian masses (6 malignant, 4 nonmalignant). All cases of cancer were histologically proven; however, 2 cases of nonrecurrent uterine cervical carcinomas were diagnosed by clinical course. Continuous bladder irrigation was performed 35–55 min after intravenous administration of 185–370 MBq 18F-FDG, and an emission scan was obtained 40–55 min after intravenous administration. Standardized uptake value (SUV) was used to estimate the degree of 18F-FDG uptake quantitatively. Results: After bladder irrigation, the 18F-FDG activity in the urinary tract was eliminated in 33 patients, so that detection of tumor 18F-FDG accumulation was easy. Two patients showed residual activity in the urinary bladder, and 6 patients showed activity in the ureter. An artifact was seen in 1 patient with residual activity in the urinary bladder caused by insufficient irrigation. However, these residual activities had no influence on detecting 18F-FDG accumulation in tumor. The mean (±SD) of SUVs of malignant lesions was 6.04 ± 3.22, that of nonmalignant lesions was 1.71 ± 1.12, and the difference was significant (P = 0.0002). SUVs of all malignant lesions were greater than 2.0, and SUVs of all nonmalignant lesions, except the 1 case of ovarian fibroma, were less than 2.0. Conclusion: 18F-FDG PET with continuous bladder irrigation is useful for eliminating 18F-FDG activity in the bladder and for differentiating between malignant and nonmalignant uterine or ovarian masses.