TY - JOUR T1 - <sup>123</sup>I-Metaiodobenzylguanidine Uptake in the Nape of the Neck of Children: Likely Visualization of Brown Adipose Tissue JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1421 LP - 1425 VL - 44 IS - 9 AU - Chio Okuyama AU - Yo Ushijima AU - Takao Kubota AU - Toshihide Yoshida AU - Takako Nakai AU - Kana Kobayashi AU - Tsunehiko Nishimura Y1 - 2003/09/01 UR - http://jnm.snmjournals.org/content/44/9/1421.abstract N2 - The distribution of radioiodinated metaiodobenzylguanidine (MIBG) has been studied primarily in patients with neuroendocrine tumors—in pediatrics, particularly with neuroblastomas. Sometimes, symmetric accumulation in which no tumor is identified is seen in the nape-of-the-neck region. We estimated visually whether accumulation was found in the nape of the neck and studied the characteristics of the accumulation. Methods: Retrospectively, we investigated 266 123I-MIBG scintigraphic studies performed on pediatric patients who had been treated for neuroendocrine tumors or who were suspected of having such tumors. Results: Accumulation in the nape of the neck was seen in 32 of 266 studies (12%); in none of these cases was the accumulation identified as a tumor by other imaging modalities or follow-up studies. In the same individuals, the accumulation varied and it was observed more often during winter. Conclusion: Symmetric 123I-MIBG accumulations in the nape-of-the-neck region observed in children are thought to be related to the uptake in brown adipose tissue. ER -