PT  - JOURNAL ARTICLE
AU  - Russell, Charles D.
TI  - A Bayesian 3-Compartment Model for <sup>99m</sup>Tc-MAG3 Clearance
DP  - 2003 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1357--1361
VI  - 44
IP  - 8
4099  - http://jnm.snmjournals.org/content/44/8/1357.short
4100  - http://jnm.snmjournals.org/content/44/8/1357.full
SO  - J Nucl Med2003 Aug 01; 44
AB  - Because recent reports have questioned the traditional 2-compartment model for calculating tracer clearance after a single intravenous injection, a 3-compartment model was evaluated in this study. Methods: Bayesian statistics were used, which facilitated curve fitting by treating all subjects simultaneously. 99mTc-Mercaptoacetyltriglycine clearance data from 154 adults and 109 children were measured at several centers, typically 6–9 plasma samples spanning 5–90 min, and fitted by 2- and 3-compartment Bayesian models. Results: Clearance estimates were found to be systematically lower for the 3-compartment model than for the 2-compartment model. A single-sample procedure based on the 3-compartment model was found to eliminate most of the known discrepancy between formulas based on single-injection and continuous-infusion reference methods. Conclusion: A 3-compartment model led to lower and probably more accurate clearance estimates than the conventional 2-compartment model. A new single-sample method is presented, based on the 3-compartment model as reference standard.