RT Journal Article
SR Electronic
T1 Clinically Significant Inaccurate Localization of Lesions with PET/CT: Frequency in 300 Patients
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 240
OP 243
VO 44
IS 2
A1 Medhat M. Osman
A1 Christian Cohade
A1 Yuji Nakamoto
A1 Laura T. Marshall
A1 Jeff P. Leal
A1 Richard L. Wahl
YR 2003
UL http://jnm.snmjournals.org/content/44/2/240.abstract
AB This study evaluated lesion mislocalization between PET and CT on PET/CT studies when CT instead of germanium is used for attenuation correction (AC). Methods: PET/CT scans were obtained for 300 clinical patients. Both CT and germanium scans were used to correct PET emission data. Cases were noted of suspected inaccurate localization of lesions on any of the 5 sets of images (PET using germanium AC [GeAC] fused and not fused with CT, PET using CT AC fused and not fused with CT, and PET with no AC [NAC]). Independent CT or MRI was used to determine true lesion locations. Results: Six of 300 patients (2%) had lesion mislocalization when CT was used for AC or fusion. True liver dome lesions were mislocalized to the right lung base on PET/CT, likely because of a respiratory motion difference between PET and CT. No mislocalization was present on NAC PET or non-CT-fused GeAC PET images. Conclusion: Serious lesion mislocalization on PET/CT studies may occur, albeit very infrequently, when CT is used for either AC or fusion.