RT Journal Article SR Electronic T1 18F-FDG PET Versus CT for Evaluating the Spleen During Initial Staging of Lymphoma JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1072 OP 1074 VO 44 IS 7 A1 Josephine N. Rini A1 John C. Leonidas A1 Maria B. Tomas A1 Christopher J. Palestro YR 2003 UL http://jnm.snmjournals.org/content/44/7/1072.abstract AB The purpose of this study was to compare 18F-FDG PET to CT for evaluating the spleen during the initial staging of lymphoma. Methods: Seven patients with newly diagnosed lymphoma underwent 18F-FDG PET and CT. Splenic uptake of 18F-FDG, diffuse or focal, greater than hepatic uptake was interpreted as consistent with tumor. CT demonstrating a positive splenic index or focal hypodensities was classified as positive for tumor. PET and CT results were compared with final diagnoses, which were confirmed surgically for 6 patients and at autopsy for 1 patient. Results: Five of 7 patients had lymphomatous involvement of the spleen. 18F-FDG PET was true-positive for all 5 patients with splenic disease and true-negative for both patients without splenic disease. CT, in contrast, was true-positive for 4 of the 5 patients with splenic disease and false-positive for the 2 patients without splenic disease. The accuracies of 18F-FDG PET and CT for evaluating the spleen were 100% and 57%, respectively. Conclusion:18F-FDG PET correctly identified all patients with and without splenic disease and was superior to CT for this purpose.