PT  - JOURNAL ARTICLE
AU  - Josephine N. Rini
AU  - John C. Leonidas
AU  - Maria B. Tomas
AU  - Christopher J. Palestro
TI  - <sup>18</sup>F-FDG PET Versus CT for Evaluating the Spleen During Initial Staging of Lymphoma
DP  - 2003 Jul 01
TA  - Journal of Nuclear Medicine
PG  - 1072--1074
VI  - 44
IP  - 7
4099  - http://jnm.snmjournals.org/content/44/7/1072.short
4100  - http://jnm.snmjournals.org/content/44/7/1072.full
SO  - J Nucl Med2003 Jul 01; 44
AB  - The purpose of this study was to compare 18F-FDG PET to CT for evaluating the spleen during the initial staging of lymphoma. Methods: Seven patients with newly diagnosed lymphoma underwent 18F-FDG PET and CT. Splenic uptake of 18F-FDG, diffuse or focal, greater than hepatic uptake was interpreted as consistent with tumor. CT demonstrating a positive splenic index or focal hypodensities was classified as positive for tumor. PET and CT results were compared with final diagnoses, which were confirmed surgically for 6 patients and at autopsy for 1 patient. Results: Five of 7 patients had lymphomatous involvement of the spleen. 18F-FDG PET was true-positive for all 5 patients with splenic disease and true-negative for both patients without splenic disease. CT, in contrast, was true-positive for 4 of the 5 patients with splenic disease and false-positive for the 2 patients without splenic disease. The accuracies of 18F-FDG PET and CT for evaluating the spleen were 100% and 57%, respectively. Conclusion:18F-FDG PET correctly identified all patients with and without splenic disease and was superior to CT for this purpose.