RT Journal Article SR Electronic T1 Quantification of Dopamine Transporter by 123I-PE2I SPECT and the Noninvasive Logan Graphical Method in Parkinson’s Disease JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 663 OP 670 VO 44 IS 5 A1 Prunier, Caroline A1 Payoux, Pierre A1 Guilloteau, Denis A1 Chalon, Sylvie A1 Giraudeau, Bruno A1 Majorel, Cynthia A1 Tafani, Mathieu A1 Bezard, Erwan A1 Esquerré, Jean-Paul A1 Baulieu, Jean-Louis YR 2003 UL http://jnm.snmjournals.org/content/44/5/663.abstract AB (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy-3β-(4′-methyl-phenyl) nortropane (PE2I), a cocaine analog, is a new, highly specific tracer for imaging dopamine transporter labeled with 123I for in vivo SPECT. Its reversible binding on dopamine transporter and its rapid kinetics allow quantification of its binding potential according to a 3-compartment model. For quantification of distribution volume of reversible tracer, Logan developed a noninvasive and graphical method that allows accurate estimation of binding potential. In this study, we performed 123I-PE2I SPECT on healthy volunteers and patients with Parkinson’s disease (PD) to validate the Logan graphical method for quantification of 123I-PE2I binding and to analyze the relationship between 123I-PE2I SPECT and clinical features of this frequent degenerative disease. Methods: Eight PD patients (3 women, 5 men; mean age, 64 ± 7.9 y; disease duration range, 1–8 y, Hoehn and Yahr stage range, 1–2.5) and 8 age-matched healthy volunteers (4 women, 4 men; mean age, 61.5 ± 9.5 y) were included in 2 centers and studied with SPECT. Four sequential SPECT imaging sessions of 15-min duration were performed from 5 to 65 min after bolus injection of 140 ± 30 MBq of 123I-PE2I. Results: The kinetics of PE2I in healthy volunteers and PD patients were rapid, and the Logan graphical method allowed quantification of distribution volume ratio (DVR) in the caudate nucleus and putamen. 123I-PE2I striatal specific binding was significantly reduced in PD patients, compared with healthy volunteers, in the caudate and putamen. The decrease of DVR in the putamen was significantly and inversely correlated to disease duration and Hoehn and Yahr stage. In asymmetric PD patients, 123I-PE2I uptake was significantly more reduced in the putamen contralateral to the side with predominant clinical symptoms. However, 123I-PE2I uptake was also significantly reduced in the ipsilateral putamen, compared with that in healthy volunteers, suggesting that 123I-PE2I SPECT can detect nigrostriatal degeneration before the appearance of clinical symptoms. Conclusion: Our data indicate that the Logan graphical method is accurate for noninvasive quantification of PE2I and that 123I-PE2I SPECT is a useful quantitative method for accurate estimation of nigrostriatal dopaminergic nerve terminal degeneration. The close relationships between SPECT findings and clinical data suggest that this method is useful for objectively following the progression of PD and for assessing the effect of potential neuroprotective treatments. Finally, our findings suggest that 123I-PE2I SPECT can be used for preclinical and early diagnosis of PD.