PT  - JOURNAL ARTICLE
AU  - Yu Kyeong Kim
AU  - Dong Soo Lee
AU  - Sang Kun Lee
AU  - Chun Kee Chung
AU  - June-Key Chung
AU  - Myung Chul Lee
TI  - &lt;sup&gt;18&lt;/sup&gt;F-FDG PET in Localization of Frontal Lobe Epilepsy: Comparison of Visual and SPM Analysis
DP  - 2002 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1167--1174
VI  - 43
IP  - 9
4099  - http://jnm.snmjournals.org/content/43/9/1167.short
4100  - http://jnm.snmjournals.org/content/43/9/1167.full
SO  - J Nucl Med2002 Sep 01; 43
AB  - The sensitivity of 18F-FDG PET to localize epileptogenic zones in frontal lobe epilepsy was evaluated by both visual assessment and statistical parametric mapping (SPM). Methods: Twenty-nine patients with frontal lobe epilepsy were examined. All patients showed good outcome after surgical resection (Engel class I or II). On pathologic examination, 22 patients had cortical dysplasia, 4 had tumors, 1 had cortical scars, and 2 had an old infarct. Hypometabolic lesions were found on 18F-FDG PET images by both visual assessment and SPM analysis. On SPM analysis, the cutoff threshold was varied and sensitivity to find epileptogenic zones was compared. Results: MRI showed structural lesions in 15 patients and normal findings in 14. 18F-FDG PET correctly localized the epileptogenic zones in 16 patients (55%) by visual assessment. The sensitivity of 18F-FDG PET was 36% in patients without structural lesions on MRI and 73% in patients with structural lesions. On SPM analysis, using an uncorrected probability value of 0.005 as the threshold, the sensitivity of SPM analysis was 66%, which was not statistically different from the sensitivity of visual assessment. The sensitivity decreased according to the decrease in probability value. Conclusion: 18F-FDG PET was sensitive in localizing epileptogenic zones by revealing hypometabolic areas in nonlesional patients with frontal lobe epilepsy as well as in lesional patients. SPM analysis showed a comparable sensitivity to visual assessment and could be used as an aid in diagnosing epileptogenic zones in frontal lobe epilepsy.