RT Journal Article
SR Electronic
T1 The FDG Lumped Constant in Normal Human Brain
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1157
OP 1166
VO 43
IS 9
A1 Michael M. Graham
A1 Mark Muzi
A1 Alexander M. Spence
A1 Finbarr O’Sullivan
A1 Thomas K. Lewellen
A1 Jeanne M. Link
A1 Kenneth A. Krohn
YR 2002
UL http://jnm.snmjournals.org/content/43/9/1157.abstract
AB The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using 1-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.