PT  - JOURNAL ARTICLE
AU  - Michael M. Graham
AU  - Mark Muzi
AU  - Alexander M. Spence
AU  - Finbarr O’Sullivan
AU  - Thomas K. Lewellen
AU  - Jeanne M. Link
AU  - Kenneth A. Krohn
TI  - The FDG Lumped Constant in Normal Human Brain
DP  - 2002 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1157--1166
VI  - 43
IP  - 9
4099  - http://jnm.snmjournals.org/content/43/9/1157.short
4100  - http://jnm.snmjournals.org/content/43/9/1157.full
SO  - J Nucl Med2002 Sep 01; 43
AB  - The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using 1-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.