TY - JOUR T1 - Pharmacokinetics and Radiation Dosimetry of <sup>18</sup>F-Fluorocholine JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 92 LP - 96 VL - 43 IS - 1 AU - Timothy R. DeGrado AU - Robert E. Reiman AU - David T. Price AU - Shuyan Wang AU - R. Edward Coleman Y1 - 2002/01/01 UR - http://jnm.snmjournals.org/content/43/1/92.abstract N2 - 18F-Fluorocholine (fluoromethyl-dimethyl-2-hydroxyethylammonium [FCH]) has been developed as an oncologic probe for PET. This study evaluates the kinetics and radiation dosimetry of 18F-FCH using murine and human biodistribution data. Methods: The biodistribution of 18F-FCH was obtained at time points up to 10 h after administration in control and tumor-bearing anesthetized nude mice. Human biodistribution data within the first hour after injection were obtained from attenuation-corrected whole-body PET scans of male (n = 7) and female (n = 5) cancer patients. Radiation dosimetry estimates were calculated using the murine and human biodistribution data assuming no redistribution of tracer after 1 h. Results: Rapid pharmacokinetics were observed for 18F-FCH in mice and humans. The biodistribution is nearly static after 10 min. The dose-critical organ is the kidney, which receives 0.17 ± 0.05 and 0.16 ± 0.07 mSv/MBq (0.64 ± 0.18 and 0.55 ± 0.32 rad/mCi) for females and males, respectively. The effective dose equivalent (whole body) from administration of 4.07 MBq/kg (0.110 mCi/kg) is approximately 0.01 Sv for females and males. Conclusion: 18F-FCH is rapidly cleared from the circulation and its biodistribution changes very slowly at &gt;10 min after administration. The kidney is the dose-critical organ and limits administration levels of 18F-FCH to 4.07 MBq/kg (0.110 mCi/kg) in human research studies. ER -