PT - JOURNAL ARTICLE AU - Kotaro Higashi AU - Yoshimichi Ueda AU - Yukiko Arisaka AU - Tsutomu Sakuma AU - Yoshihiro Nambu AU - Manabu Oguchi AU - Hiroyasu Seki AU - Suzuka Taki AU - Hisao Tonami AU - Itaru Yamamoto TI - <sup>18</sup>F-FDG Uptake as a Biologic Prognostic Factor for Recurrence in Patients with Surgically Resected Non–Small Cell Lung Cancer DP - 2002 Jan 01 TA - Journal of Nuclear Medicine PG - 39--45 VI - 43 IP - 1 4099 - http://jnm.snmjournals.org/content/43/1/39.short 4100 - http://jnm.snmjournals.org/content/43/1/39.full SO - J Nucl Med2002 Jan 01; 43 AB - Among patients with resected non–small cell lung cancer (NSCLC), approximately 50% present with a recurrent tumor. The clinical or pathologic TNM staging does not always provide a satisfactory explanation for differences in relapse and survival. Thus, it is of major importance to be able to predict these relapses and to prevent them with an active chemotherapy or radiotherapy program (or both). 18F-FDG uptake on PET could be of prognostic significance in patients with resected NSCLC. The goal of this study was to determine whether the level of metabolic activity observed with 18F-FDG uptake correlates with the probability of postoperative recurrence in patients with NSCLC. Methods: Fifty-seven patients with NSCLC were examined with 18F-FDG PET. For semiquantitative analysis, standardized uptake values (SUVs) were calculated. Patients were classified into high-SUV (&gt;5.0) and low-SUV (≤5.0) groups. All patients underwent thoracotomy within 4 wk after the 18F-FDG PET study. Tumor 18F-FDG uptake (SUV), pathologic stage, and lesion size were analyzed for their possible association with disease-free survival. Results: Forty-six patients had pathologic stage I NSCLC and 11 had pathologic stage II or stage III NSCLC. In a univariate analysis, patients with an SUV of ≤5 had a much better disease-free survival than did patients with an SUV of &gt;5 (P &lt; 0.0001). In patients with pathologic stage I and stage IA NSCLC, the SUV was also correlated with disease-free survival (P &lt; 0.0001 and P = 0.0012, respectively). Patients with pathologic stage I disease had an expected 5-y disease-free survival rate of 88% if the SUV was ≤5 and a survival rate of ≤17% if the SUV was &gt;5. A multivariate Cox analysis identified the SUV as the most significant independent factor for disease-free survival. Conclusion: We conclude that the 18F-FDG uptake in primary NSCLC determined by PET has a significant independent postoperative prognostic value for recurrence, especially in patients with pathologic stage I NSCLC. 18F-FDG uptake was superior to pathologic stage in predicting relapse of patients with NSCLC.