TY - JOUR T1 - Color and Power Doppler Sonography Versus DMSA Scintigraphy in Acute Pyelonephritis and in Prediction of Renal Scarring JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 27 LP - 32 VL - 43 IS - 1 AU - Anne Hitzel AU - Agnès Liard AU - Pierre Véra AU - Alain Manrique AU - Jean-François Ménard AU - Jean-Nicolas Dacher Y1 - 2002/01/01 UR - http://jnm.snmjournals.org/content/43/1/27.abstract N2 - Capabilities of color and power Doppler sonography (DS) were prospectively evaluated for diagnosis of acute pyelonephritis and for prediction of scarring by comparison with 99mTc-dimercaptosuccinic acid scintigraphy (DMSA). Methods: Fifty-seven children (mean age, 5 ± 3 y) with acute pyelonephritis were investigated by biologic testing, DS (DS 1), and DMSA (DMSA 1). Patients who were <6 mo old or had high-grade reflux or obstruction were excluded. Forty-five children had a clinical follow-up examination, biologic testing, DS (DS 2), and DMSA (DMSA 2) at a mean of 7 ± 2 mo after acute infection. Sonography (gray-scale and DS) was performed by 1 experienced radiologist who was unaware of patient data. DMSA studies were interpreted by 2 physicians who were unaware of patient data. Results: Temperature, neutrophil count, and C-reactive protein value were significantly higher in patients with abnormal DMSA 1 findings than in those with abnormal DS 1 findings (P < 0.05). When compared with DMSA 1, DS 1 had a sensitivity and specificity of 80% and 81%, respectively. At follow-up, all clinical and biologic data had normalized. Scarring after infection occurred in 51% of children. When compared with DMSA 2, DS 1 had positive and negative predictive values of 57% and 75%, respectively, and DMSA 1 had respective values of 62% and 100%. Reflux was not considered a good predictor of scarring. Conclusion: DS and DMSA results were concordant in 81% of kidneys with acute pyelonephritis. The predictive value of DS for renal scarring was not considered sufficiently high for DS to be used in routine practice. ER -