PT  - JOURNAL ARTICLE
AU  - T. Lee Collier
AU  - Yuying Hwang
AU  - Ravichandran Ramasamy
AU  - Robert R. Sciacca
AU  - Kathleen T. Hickey
AU  - Norman R. Simpson
AU  - Steven R. Bergmann
TI  - Synthesis and Initial Evaluation of 17-<sup>11</sup>C-Heptadecanoic Acid for Measurement of Myocardial Fatty Acid Metabolism
DP  - 2002 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1707--1714
VI  - 43
IP  - 12
4099  - http://jnm.snmjournals.org/content/43/12/1707.short
4100  - http://jnm.snmjournals.org/content/43/12/1707.full
SO  - J Nucl Med2002 Dec 01; 43
AB  - Fatty acid oxidation defects are being increasingly identified as causes of abnormal heart function and sudden death in children. Children with medium-chain acyl-coenzyme A (acyl-CoA) dehydrogenase defects can metabolize fatty acids labeled in the carboxylic acid end of the compound. Accordingly, our goal was to label a long-chain fatty acid in the ω-position and evaluate its myocardial kinetics. Methods: Heptadecanoic acid, a 17-carbon fatty acid, was labeled in the C-17 position with 11C by the general process of coupling 11C-methyliodide to t-butyl-15-hexadecanoate. Yield was ∼5%–10% end-of-bombardment. Subsequently, evaluation studies were performed on isolated perfused rat hearts and in intact, anesthetized dogs. The myocardial uptake and efflux of 17-11C-heptadecanoic acid were compared with those of 1-11C-palmitate. Results: With the exception of delayed efflux of tracer reflecting the temporal delay for β-oxidation, the washout of 17-11C-heptadecanoic acid from the heart mirrored that of 1-11C-palmitate in isolated rat hearts and in intact dogs with PET. Conclusion: 17-11C-Heptadecanoic acid may be a useful tracer for the identification of defects in fatty acid metabolism in subjects with medium- and short-chain fatty acid oxidation defects.