%0 Journal Article
%A Vicky Caveliers
%A Hendrik Everaert
%A Christy S. John
%A Tony Lahoutte
%A Axel Bossuyt
%T Sigma Receptor Scintigraphy with N-[2-(1′-Piperidinyl)Ethyl]-3-123I-Iodo-4-Methoxybenzamide of Patients with Suspected Primary Breast Cancer: First Clinical Results
%D 2002
%J Journal of Nuclear Medicine
%P 1647-1649
%V 43
%N 12
%X The aim of this study was to investigate the potential of a new iodobenzamide, N-[2-(1′-piperidinyl)ethyl]-3-123I-iodo-4-methoxybenzamide (P-123I-MBA), to visualize primary breast tumor in humans in vivo. Tumor accumulation of benzamides is based on a preferential binding to sigma receptors that are overexpressed on breast cancer cells. Methods: P-123I-MBA (148–185 MBq) was administered to 12 patients with a mammographically suspicious breast mass. Two hours after administration, whole-body and spot images of the healthy and the diseased breast were obtained. Results: A focal increased tracer accumulation was observed in 8 of 10 patients with histologically confirmed breast cancer (mean tumor-to-background ratio, 2.04). No uptake was seen in a case of lymphatic adenitis. Conclusion: This preliminary patient study shows that P-123I-MBA accumulates in most breast tumors in vivo. Future work should focus on the relationship between P-123I-MBA uptake and the proliferative activity of cells to anticipate use of this technique as a tool to noninvasively assess the degree of tumor proliferation.
%U https://jnm.snmjournals.org/content/jnumed/43/12/1647.full.pdf