@article {Lebtahi889, author = {Rachida Lebtahi and Joseph Le Cloirec and Claire Houzard and Doumit Daou and Iradj Sobhani and Genevi{\`e}ve Sassolas and Michel Mignon and Patrick Bourguet and Dominique Le Guludec}, title = {Detection of Neuroendocrine Tumors: 99mTc-P829 Scintigraphy Compared with 111In-Pentetreotide Scintigraphy }, volume = {43}, number = {7}, pages = {889--895}, year = {2002}, publisher = {Society of Nuclear Medicine}, abstract = {The aim of this study was to evaluate the diagnostic value of a new somatostatin analog, 99mTc-P829, compared with that of 111In-pentetreotide. Methods: Forty-three patients (32 men, 11 women; age range, 24{\textendash}78 y; mean age, 56 y) with biologically or histologically proven neuroendocrine tumors were prospectively included: 11 patients with Zollinger-Ellison syndrome, 16 patients with carcinoid tumors, and 16 patients with other types of functioning (n = 6) or nonfunctioning (n = 10) endocrine tumors. 111In-Pentetreotide planar images (head, chest, abdomen, and pelvis) were obtained 4 and 24 h after injection of 10 μg somatostatin analog labeled with 148 {\textpm} 17 MBq 111In, and SPECT was performed 24 h after injection. Similar 99mTc-P829 planar images were obtained at 1, 4{\textendash}6, and 24 h after injection of 50 μg peptide labeled with 991.6 {\textpm} 187.59 MBq 99mTc. Abdominal SPECT was performed 4{\textendash}6 h after injection. Results: 111In-Pentetreotide detected 203 tumoral sites in 39 (91\%) of 43 patients, whereas 99mTc-P829 detected 77 sites in 28 (65\%) of 43 patients (P \< 0.005). In the liver, 129 sites (in 24 patients) were detected by 111In-pentetreotide scintigraphy and 34 sites (in 10 patients) were detected by 99mTc-P829 scintigraphy. Conclusion: In patients with endocrine tumors, the detection rate of 99mTc-P829 scintigraphy was lower than that of 111In-pentetreotide scintigraphy, which appeared to be more sensitive, especially for liver metastases.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/43/7/889}, eprint = {https://jnm.snmjournals.org/content/43/7/889.full.pdf}, journal = {Journal of Nuclear Medicine} }