RT Journal Article SR Electronic T1 Evaluation of Left Ventricular Function Using Electrocardiographically Gated Myocardial SPECT with 123I-Labeled Fatty Acid Analog JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1747 OP 1756 VO 42 IS 12 A1 Mamoru Nanasato A1 Akitada Ando A1 Satoshi Isobe A1 Makoto Nonokawa A1 Haruo Hirayama A1 Naoya Tsuboi A1 Teruo Ito A1 Makoto Hirai A1 Mitsuhiro Yokota A1 Hidehiko Saito YR 2001 UL http://jnm.snmjournals.org/content/42/12/1747.abstract AB Electrocardiographically (ECG) gated myocardial SPECT with 99mTc-tetrofosmin has been used widely to assess left ventricular (LV) function. However, the accuracy of variables using ECG gated myocardial SPECT with β-methyl-p-123I-iodophenylpentadecanoic acid (BMIPP) has not been well defined. Methods: Thirty-six patients (29 men, 7 women; mean age, 61.6 ± 15.6 y) with ischemic heart disease underwent ECG gated myocardial SPECT with 123I-BMIPP and with 99mTc-tetrofosmin and left ventriculography (LVG) within 1 wk. LV ejection fraction (LVEF), LV end-diastolic volume (LVEDV), and LV end-systolic volume (LVESV) were determined on gated SPECT using commercially available software for automatic data analysis. These volume-related items on LVG were calculated with an area–length method and were estimated by 2 independent observers to evaluate interobserver validity. The regional wall motion with these methods was assessed visually. Results: LVEF was 41.1% ± 12.5% on gated SPECT with 123I-BMIPP, 44.5% ± 13.1% on gated SPECT with 99mTc-tetrofosmin, and 46.0% ± 12.7% on LVG. Global LV function and regional wall motion between both gated SPECT procedures had excellent correlation (LVEF, r = 0.943; LVEDV, r = 0.934; LVESV, r = 0.952; regional wall motion, κ = 0.92). However, the correlations of global LV function and regional wall motion between each gated SPECT and LVG were significantly lower. Gated SPECT with 123I-BMIPP showed the same interobserver validity as gated SPECT with 99mTc-tetrofosmin. Conclusion: Gated SPECT with 123I-BMIPP provides high accuracy with regard to LV function and is sufficiently applicable for use in clinical SPECT. This technique can simultaneously reveal myocardial fatty acid metabolism and LV function, which may be useful to evaluate various cardiac diseases.