RT Journal Article
SR Electronic
T1 Imaging of Human Infection with <sup>131</sup>I-Labeled Recombinant Human Interleukin-8
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1656
OP 1659
VO 42
IS 11
A1 Gross, Milton D.
A1 Shapiro, Brahm
A1 Fig, Lorraine M.
A1 Steventon, Robert
A1 Skinner, Richard W.S.
A1 Hay, Rick V.
YR 2001
UL http://jnm.snmjournals.org/content/42/11/1656.abstract
AB The chemotactic cytokine interleukin-8 (IL-8) plays an important role in attraction and activation of polymorphonuclear leukocytes in infection and inflammation. A pilot study was conducted to determine if radiolabeled IL-8 would depict infection in humans. Methods: Human recombinant IL-8 (rhIL-8) labeled with 131I (specific activity, 0.4–0.7 MBq [11–18 μCi] 131I/μg IL-8) was injected intravenously into 8 diabetic patients with active foot infections and evidence of osteomyelitis, 2 patients with successfully treated osteomyelitis, and 1 patient with cellulitis of the thumb. Results: Focal accumulation of 131I-rhIL-8 was seen in 8 of 8 patients with active foot infection and diffuse uptake was seen in the thumb of the 1 patient with cellulitis. In the 2 patients with successfully treated bone infection, multiphase 99mTc-hydroxyethylene diphosphonate bone scans were negative early, but late-phase (&gt;3 h) uptake depicted degenerative lesions that did not image with 131I-rhIL-8. Conclusion: 131I-rhIL-8 accumulates rapidly within infected foci in osteomyelitis and cellulitis but not in successfully treated infections or degenerative joint disease.