RT Journal Article
SR Electronic
T1 Comparison of 1-<sup>11</sup>C-Glucose and <sup>18</sup>F-FDG for Quantifying Myocardial Glucose Use with PET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1530
OP 1541
VO 43
IS 11
A1 Herrero, Pilar
A1 Sharp, Terry L.
A1 Dence, Carmen
A1 Haraden, Brendan M.
A1 Gropler, Robert J.
YR 2002
UL http://jnm.snmjournals.org/content/43/11/1530.abstract
AB In this study, we compared the accuracy of the rate of myocardial glucose use (rMGU) measured using PET and 1-11C-glucose with the rate measured using PET and the more conventional tracer 18F-FDG. Methods: PET measurements of myocardial tracer uptake (K, in mL/g/min) and rMGU (in nmol/g/min) were obtained with 1-11C-glucose and 18F-FDG in 21 dogs using kinetic modeling and the Patlak graphical method, respectively. Eighteen dogs were studied during hyperinsulinemic-euglycemic clamp performed either at rest or combined with phenylephrine, dobutamine, intralipid infusion, or intralipid infusion and dobutamine. Three dogs were studied during intralipid infusion alone under resting conditions. Arterial-coronary sinus sampling was performed to measure the K of both tracers (n = 14) and rMGU by the Fick method (n = 21). Results: PET-derived values for K from either 1-11C-glucose or 18F-FDG correlated closely with directly measured tracer K values (glucose: y = 0.98x + 0.01, r = 0.79, P &lt; 0.001; 18F-FDG: y = 0.74x + 0.03, r = 0.77, P &lt; 0.001). In contrast, correlation with K values of unlabeled glucose measured directly was better for 1-11C-glucose (y = 0.92x + 0.02, r = 0.96, P &lt; 0.0001) than for 18F-FDG (y = 0.66x + 0.05, r = 0.72, P &lt; 0.01) (P &lt; 0.001 for comparison of correlation coefficients). As a consequence, PET-derived values for rMGU correlated more closely with Fick-derived measurements of unlabeled glucose using 1-11C-glucose (y = 0.82x + 168, r = 0.97, P &lt; 0.0001) than with 18F-FDG (y = 0.81x + 278, r = 0.79, P &lt; 0.001) (P &lt; 0.001 for comparison of correlation coefficients). Conclusion: Over a wide range of conditions, PET-derived measurements of rMGU are obtained more accurately with 1-11C-glucose than with 18F-FDG.