%0 Journal Article %A Pilar Herrero %A Terry L. Sharp %A Carmen Dence %A Brendan M. Haraden %A Robert J. Gropler %T Comparison of 1-11C-Glucose and 18F-FDG for Quantifying Myocardial Glucose Use with PET %D 2002 %J Journal of Nuclear Medicine %P 1530-1541 %V 43 %N 11 %X In this study, we compared the accuracy of the rate of myocardial glucose use (rMGU) measured using PET and 1-11C-glucose with the rate measured using PET and the more conventional tracer 18F-FDG. Methods: PET measurements of myocardial tracer uptake (K, in mL/g/min) and rMGU (in nmol/g/min) were obtained with 1-11C-glucose and 18F-FDG in 21 dogs using kinetic modeling and the Patlak graphical method, respectively. Eighteen dogs were studied during hyperinsulinemic-euglycemic clamp performed either at rest or combined with phenylephrine, dobutamine, intralipid infusion, or intralipid infusion and dobutamine. Three dogs were studied during intralipid infusion alone under resting conditions. Arterial-coronary sinus sampling was performed to measure the K of both tracers (n = 14) and rMGU by the Fick method (n = 21). Results: PET-derived values for K from either 1-11C-glucose or 18F-FDG correlated closely with directly measured tracer K values (glucose: y = 0.98x + 0.01, r = 0.79, P < 0.001; 18F-FDG: y = 0.74x + 0.03, r = 0.77, P < 0.001). In contrast, correlation with K values of unlabeled glucose measured directly was better for 1-11C-glucose (y = 0.92x + 0.02, r = 0.96, P < 0.0001) than for 18F-FDG (y = 0.66x + 0.05, r = 0.72, P < 0.01) (P < 0.001 for comparison of correlation coefficients). As a consequence, PET-derived values for rMGU correlated more closely with Fick-derived measurements of unlabeled glucose using 1-11C-glucose (y = 0.82x + 168, r = 0.97, P < 0.0001) than with 18F-FDG (y = 0.81x + 278, r = 0.79, P < 0.001) (P < 0.001 for comparison of correlation coefficients). Conclusion: Over a wide range of conditions, PET-derived measurements of rMGU are obtained more accurately with 1-11C-glucose than with 18F-FDG. %U https://jnm.snmjournals.org/content/jnumed/43/11/1530.full.pdf