RT Journal Article
SR Electronic
T1 An Introduction to PET and SPECT Neuroreceptor Quantification Models*
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 755
OP 763
VO 42
IS 5
A1 Ichise, Masanori
A1 Meyer, Jeffrey H.
A1 Yonekura, Yoshiharu
YR 2001
UL http://jnm.snmjournals.org/content/42/5/755.abstract
AB PET and SPECT using appropriate radioligands allow imaging of certain critical components of neurotransmission such as presynaptic transporters and postsynaptic receptors in living human brains. PET and SPECT data are commonly analyzed by applying tracer kinetic models. These modeling approaches assume a compartmental system and derive the outcome measure called the binding potential, which reflects the densities of transporters or receptors in a brain region of interest. New models are often noninvasive in that they do not require arterial blood sampling. In this review, the concept and principles of tracer kinetic modeling are introduced and commonly used PET and SPECT neuroreceptor quantification models are discussed.