RT Journal Article
SR Electronic
T1 Uptake of Cis-4-[<sup>18</sup>F]Fluoro-<span class="sc">l</span>-Proline in Urologic Tumors
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 752
OP 754
VO 42
IS 5
A1 Langen, Karl-Josef
A1 Börner, Anne Rose
A1 Müller-Mattheis, Volker
A1 Hamacher, Kurt
A1 Herzog, Hans
A1 Ackermann, Rolf
A1 Coenen, Heinz H.
YR 2001
UL http://jnm.snmjournals.org/content/42/5/752.abstract
AB Tumor uptake of the amino acid cis-4-[18F]fluoro-l-proline (cis-FPro) was studied with PET in eight patients with urologic tumors. Methods: Three patients had primary renal cell carcinomas (RCCs), one had a local recurrence of RCC, one had squamous RCC, one had an adrenal hemangioma, one had inguinal metastases of penile squamous carcinoma, and one had suspected metastatic disease from prostate cancer. PET scans of the trunk were acquired at 1 and 3–5 h after intravenous injection of 400 MBq cis-FPro and compared with 18F-FDG PET scans and CT. Results: None of the tumors or metastases showed significant uptake of cis-FPro. FDG uptake was seen in one of the three primary RCCs, in the local recurrence of RCC, in the squamous RCC, and in the metastases of penile cancer. Conclusion: Cis-FPro appears not to be a promising PET tracer in oncology.