PT  - JOURNAL ARTICLE
AU  - Langen, Karl-Josef
AU  - Börner, Anne Rose
AU  - Müller-Mattheis, Volker
AU  - Hamacher, Kurt
AU  - Herzog, Hans
AU  - Ackermann, Rolf
AU  - Coenen, Heinz H.
TI  - Uptake of Cis-4-[<sup>18</sup>F]Fluoro-<span class="sc">l</span>-Proline in Urologic Tumors
DP  - 2001 May 01
TA  - Journal of Nuclear Medicine
PG  - 752--754
VI  - 42
IP  - 5
4099  - http://jnm.snmjournals.org/content/42/5/752.short
4100  - http://jnm.snmjournals.org/content/42/5/752.full
SO  - J Nucl Med2001 May 01; 42
AB  - Tumor uptake of the amino acid cis-4-[18F]fluoro-l-proline (cis-FPro) was studied with PET in eight patients with urologic tumors. Methods: Three patients had primary renal cell carcinomas (RCCs), one had a local recurrence of RCC, one had squamous RCC, one had an adrenal hemangioma, one had inguinal metastases of penile squamous carcinoma, and one had suspected metastatic disease from prostate cancer. PET scans of the trunk were acquired at 1 and 3–5 h after intravenous injection of 400 MBq cis-FPro and compared with 18F-FDG PET scans and CT. Results: None of the tumors or metastases showed significant uptake of cis-FPro. FDG uptake was seen in one of the three primary RCCs, in the local recurrence of RCC, in the squamous RCC, and in the metastases of penile cancer. Conclusion: Cis-FPro appears not to be a promising PET tracer in oncology.