RT Journal Article SR Electronic T1 Detection of Esophagitis by 99mTc-Methoxyisobutylisonitrile Chest SPECT JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1969 OP 1972 VO 41 IS 12 A1 Chia-Hung Kao A1 Jih-Fang Hsieh A1 Shih-Chuan Tsai A1 Yung-Jen Ho A1 Shung-Shung Sun YR 2000 UL http://jnm.snmjournals.org/content/41/12/1969.abstract AB Esophagitis is a common complication of gastroesophageal reflux disease (GERD). Unfortunately, an accurate diagnosis of esophagitis usually requires invasive endoscopy. The purpose of our study was to evaluate the use of noninvasive 99mTc-methoxyisobutylisonitrile (MIBI) chest SPECT to detect esophagitis in GERD patients. Methods: Forty GERD patients who underwent endoscopy for diagnosis and grading of esophagitis according to the Savary–Miller grading system were included in this study. 99mTc-MIBI chest SPECT was performed on all patients to detect and grade esophagitis. Results: On the basis of the endoscopic findings, the sensitivity, specificity, and accuracy of 99mTc-MIBI chest SPECT to detect esophagitis were 100%, 77%, and 95%, respectively. The correlation between the Savary–Miller grading system and 99mTc-MIBI chest SPECT grading was found to be good. Conclusion: Noninvasive 99mTc-MIBI chest SPECT has excellent sensitivity and good accuracy as a screen for esophagitis.