PT  - JOURNAL ARTICLE
AU  - Kao, Chia-Hung
AU  - Hsieh, Jih-Fang
AU  - Tsai, Shih-Chuan
AU  - Ho, Yung-Jen
AU  - Sun, Shung-Shung
TI  - Detection of Esophagitis by <sup>99m</sup>Tc-Methoxyisobutylisonitrile Chest SPECT
DP  - 2000 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 1969--1972
VI  - 41
IP  - 12
4099  - http://jnm.snmjournals.org/content/41/12/1969.short
4100  - http://jnm.snmjournals.org/content/41/12/1969.full
SO  - J Nucl Med2000 Dec 01; 41
AB  - Esophagitis is a common complication of gastroesophageal reflux disease (GERD). Unfortunately, an accurate diagnosis of esophagitis usually requires invasive endoscopy. The purpose of our study was to evaluate the use of noninvasive 99mTc-methoxyisobutylisonitrile (MIBI) chest SPECT to detect esophagitis in GERD patients. Methods: Forty GERD patients who underwent endoscopy for diagnosis and grading of esophagitis according to the Savary–Miller grading system were included in this study. 99mTc-MIBI chest SPECT was performed on all patients to detect and grade esophagitis. Results: On the basis of the endoscopic findings, the sensitivity, specificity, and accuracy of 99mTc-MIBI chest SPECT to detect esophagitis were 100%, 77%, and 95%, respectively. The correlation between the Savary–Miller grading system and 99mTc-MIBI chest SPECT grading was found to be good. Conclusion: Noninvasive 99mTc-MIBI chest SPECT has excellent sensitivity and good accuracy as a screen for esophagitis.