PT - JOURNAL ARTICLE AU - Kao, Chia-Hung AU - Hsieh, Jih-Fang AU - Tsai, Shih-Chuan AU - Ho, Yung-Jen AU - Sun, Shung-Shung TI - Detection of Esophagitis by <sup>99m</sup>Tc-Methoxyisobutylisonitrile Chest SPECT DP - 2000 Dec 01 TA - Journal of Nuclear Medicine PG - 1969--1972 VI - 41 IP - 12 4099 - http://jnm.snmjournals.org/content/41/12/1969.short 4100 - http://jnm.snmjournals.org/content/41/12/1969.full SO - J Nucl Med2000 Dec 01; 41 AB - Esophagitis is a common complication of gastroesophageal reflux disease (GERD). Unfortunately, an accurate diagnosis of esophagitis usually requires invasive endoscopy. The purpose of our study was to evaluate the use of noninvasive 99mTc-methoxyisobutylisonitrile (MIBI) chest SPECT to detect esophagitis in GERD patients. Methods: Forty GERD patients who underwent endoscopy for diagnosis and grading of esophagitis according to the Savary–Miller grading system were included in this study. 99mTc-MIBI chest SPECT was performed on all patients to detect and grade esophagitis. Results: On the basis of the endoscopic findings, the sensitivity, specificity, and accuracy of 99mTc-MIBI chest SPECT to detect esophagitis were 100%, 77%, and 95%, respectively. The correlation between the Savary–Miller grading system and 99mTc-MIBI chest SPECT grading was found to be good. Conclusion: Noninvasive 99mTc-MIBI chest SPECT has excellent sensitivity and good accuracy as a screen for esophagitis.