PT  - JOURNAL ARTICLE
AU  - Parihar, Ashwin Singh
AU  - Pant, Niharika
AU  - Heidari, Pedram
AU  - Fong, Lawrence
AU  - Iravani, Amir
TI  - Approaches to Imaging Immune Activation Using PET
AID  - 10.2967/jnumed.124.268289
DP  - 2025 Apr 30
TA  - Journal of Nuclear Medicine
PG  - jnumed.124.268289
4099  - http://jnm.snmjournals.org/content/early/2025/04/30/jnumed.124.268289.short
4100  - http://jnm.snmjournals.org/content/early/2025/04/30/jnumed.124.268289.full
AB  - This review explores the role of PET in imaging immune activation, particularly in oncology. 18F-FDG is widely used for assessing treatment response to immunotherapies and can demonstrate unique response patterns as well as immune-related adverse events. However, because of the limited specificity of 18F-FDG, newer PET radiopharmaceuticals targeting specific cellular or subcellular components of the immune system have been developed that can provide more precise information. The development of immune-specific PET radiopharmaceuticals offers significant potential for improving immune monitoring in both clinical practice and research.