PT  - JOURNAL ARTICLE
AU  - Allison, Margaret B.
AU  - Catana, Ciprian
AU  - Zhou, Iris Y.
AU  - Caravan, Peter
AU  - Montesi, Sydney B.
TI  - Molecular Imaging of Pulmonary Fibrosis
AID  - 10.2967/jnumed.124.267852
DP  - 2025 Apr 01
TA  - Journal of Nuclear Medicine
PG  - 502--505
VI  - 66
IP  - 4
4099  - http://jnm.snmjournals.org/content/66/4/502.short
4100  - http://jnm.snmjournals.org/content/66/4/502.full
SO  - J Nucl Med2025 Apr 01; 66
AB  - Fibrosing lung diseases affect over 160,000 individuals in the United States alone and can carry a prognosis that is worse than many cancers. Antifibrotic treatments modify only the rate of fibrosis progression, and more effective therapies are urgently needed. Molecular imaging enables visualization of disease pathogenesis in progress. It provides a noninvasive means to monitor and quantify dysregulated molecular fibrotic pathways and shows great promise in aiding the diagnosis and disease activity monitoring of pulmonary fibrosis. Here, we review molecular imaging probes under development for use in pulmonary fibrosis. We provide our opinion on current challenges in translating preclinical molecular imaging probes into clinical successes, as well as future directions for expanding their use in drug development.