RT Journal Article SR Electronic T1 Positron Range Correction Helps Enhance the Image Quality of Cardiac 82Rb PET/CT JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 466 OP 472 DO 10.2967/jnumed.124.267855 VO 66 IS 3 A1 Lassen, Martin Lyngby A1 Kertész, Hunor A1 Rausch, Ivo A1 Panin, Vladimir A1 Conti, Maurizio A1 Zuehlsdorff, Sven A1 Cabello, Jorge A1 Bharkhada, Deepak A1 DeKemp, Robert A1 Kjaer, Andreas A1 Beyer, Thomas A1 Hasbak, Philip YR 2025 UL http://jnm.snmjournals.org/content/66/3/466.abstract AB The image quality and quantitative accuracy of 82Rb myocardial perfusion imaging (MPI) using PET is challenged by the extensive positron range (PR) effects, with the PR of 82Rb being about 7 mm in soft tissues. This study explored the feasibility of applying postacquisition PR correction (PRC) to routine 82Rb PET/CT MPI acquisitions and assessed its impact on diagnostic accuracy and image quality. Methods: We implemented a PRC method adjusted to 82Rb into a vendor-provided reconstruction toolbox, using tissue-specific corrections for soft tissue, bone, and air/lungs. The PRC was evaluated in 2 cohorts: the first comprised 25 healthy volunteers who underwent repeated 82Rb MPI within 2 wk, and the second included 66 patients with known or suspected coronary artery disease. We measured the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) for the volunteer cohort. In the patient cohort, the impact of PRC was evaluated as changes in the area under the receiver operating characteristic curve (AUC), using fractional flow reserve as the gold standard (values < 80% were considered significantly reduced). We calculated AUCs for stress and ischemic total perfusion deficits. Results: In the volunteer cohort, PRC-based reconstructions (standard reconstruction [STD] + PRC) demonstrated significantly improved SNR and CNR compared with STD, with median increases of 22% and 47% for SNR and CNR, respectively (P < 0.05). For the patient cohort, comparable AUCs were reported for STD- versus PRC-based reconstructions (stress total perfusion deficits, 0.84 vs. 0.83 [P = 0.49]; ischemic total perfusion deficits, 0.87 vs. 0.87 [P = 0.80]). Conclusion: PRC significantly enhances SNR and CNR compared with STD without affecting the diagnostic accuracy of the scans. Given the significantly improved image quality, PRC may be recommended for MPI using 82Rb PET/CT clinical-routine-assessment interpretation of TPD.