PT  - JOURNAL ARTICLE
AU  - Ceriani, Luca
AU  - Milan, Lisa
AU  - Pirosa, Maria Cristina
AU  - Martelli, Maurizio
AU  - Ruberto, Teresa
AU  - Cascione, Luciano
AU  - Johnson, Peter W.M.
AU  - Davies, Andrew J.
AU  - Ciccone, Giovannino
AU  - Zucca, Emanuele
TI  - PET-Based Risk Stratification in Primary Mediastinal B-Cell Lymphoma: A Comparative Analysis of Different Segmentation Methods in the IELSG37 Trial Patient Cohort
AID  - 10.2967/jnumed.124.268874
DP  - 2025 Feb 01
TA  - Journal of Nuclear Medicine
PG  - 209--214
VI  - 66
IP  - 2
4099  - http://jnm.snmjournals.org/content/66/2/209.short
4100  - http://jnm.snmjournals.org/content/66/2/209.full
SO  - J Nucl Med2025 Feb 01; 66
AB  - Standardizing tumor measurement on 18F-FDG PET is crucial for the routine clinical use of powerful PET-derived lymphoma prognostic factors such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The recent proposal of an SUV of 4 as a new reference segmentation threshold for most aggressive lymphomas may homogenize volume-based metrics and facilitate their clinical application. Methods: This study compared MTV and TLG in primary mediastinal B-cell lymphoma (PMBCL) patients estimated using an SUV of 4 and the current threshold at 25% of SUVmax. Baseline PET metrics were evaluated in 501 PMBCL patients from the IELSG37 trial. Results: Median MTV and TLG estimated with the 25% of SUVmax threshold were significantly lower than those obtained with the new reference threshold; however, an extremely high correlation was observed between the methods for both MTV (r = 0.95) and TLG (r = 0.99), resulting in superimposable prognostic power. Conclusion: These findings support the routine use of an SUV of 4 for volumetric measurements in PMBCL.