RT Journal Article
SR Electronic
T1 PET-Based Risk Stratification in Primary Mediastinal B-Cell Lymphoma: A Comparative Analysis of Different Segmentation Methods in the IELSG37 Trial Patient Cohort
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.124.268874
DO 10.2967/jnumed.124.268874
A1 Ceriani, Luca
A1 Milan, Lisa
A1 Pirosa, Maria Cristina
A1 Martelli, Maurizio
A1 Ruberto, Teresa
A1 Cascione, Luciano
A1 Johnson, Peter W.M.
A1 Davies, Andrew J.
A1 Ciccone, Giovannino
A1 Zucca, Emanuele
YR 2025
UL http://jnm.snmjournals.org/content/early/2025/01/16/jnumed.124.268874.abstract
AB Standardizing tumor measurement on 18F-FDG PET is crucial for the routine clinical use of powerful PET-derived lymphoma prognostic factors such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The recent proposal of an SUV of 4 as a new reference segmentation threshold for most aggressive lymphomas may homogenize volume-based metrics and facilitate their clinical application. Methods: This study compared MTV and TLG in primary mediastinal B-cell lymphoma (PMBCL) patients estimated using an SUV of 4 and the current threshold at 25% of SUVmax. Baseline PET metrics were evaluated in 501 PMBCL patients from the IELSG37 trial. Results: Median MTV and TLG estimated with the 25% of SUVmax threshold were significantly lower than those obtained with the new reference threshold; however, an extremely high correlation was observed between the methods for both MTV (r = 0.95) and TLG (r = 0.99), resulting in superimposable prognostic power. Conclusion: These findings support the routine use of an SUV of 4 for volumetric measurements in PMBCL.