RT Journal Article SR Electronic T1 Intraarterial Administration of Peptide Receptor Radionuclide Therapy in Patients with Advanced Meningioma: Initial Safety and Efficacy JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1911 OP 1916 DO 10.2967/jnumed.124.268217 VO 65 IS 12 A1 Amerein, Adriana A1 Maurer, Christoph A1 Kircher, Malte A1 Gäble, Alexander A1 Krebold, Anne A1 Rinscheid, Andreas A1 Viering, Oliver A1 Pfob, Christian H. A1 Bundschuh, Ralph A. A1 Behrens, Lars A1 Braat, Arthur JAT A1 Berlis, Ansgar A1 Lapa, Constantin YR 2024 UL http://jnm.snmjournals.org/content/65/12/1911.abstract AB Peptide receptor radionuclide therapy (PRRT) is a treatment option for patients with advanced meningioma. Recently, intraarterial application of the radiolabeled somatostatin receptor agonists has been introduced as an alternative to standard intravenous administration. In this study, we assessed the safety and efficacy of intraarterial PRRT in patients with advanced, progressive meningioma. Methods: Patients with advanced, progressive meningioma underwent intraarterial PRRT with [177Lu]Lu-HA-DOTATATE. The safety of PRRT was evaluated according to the Common Terminology Criteria for Adverse Events version 5.0. Treatment response was assessed according to the proposed Response Assessment in Neuro-Oncology criteria for meningiomas and somatostatin receptor–directed PET/CT. Results: Thirteen patients (8 women, 5 men; mean age, 65 ± 13 y) with advanced meningioma underwent 1–4 cycles (median, 4 cycles) of intraarterial PRRT with [177Lu]Lu-HA-DOTATATE (mean activity per cycle, 7,428 ± 237 MBq; range, 6,000–7,700 MBq). Treatment was well tolerated with mainly grade 1–2 hematologic toxicity. Ten of 13 patients showed radiologic disease control at follow-up after therapy (1/10 complete remission, 1/10 partial remission, 8/10 stable disease), and 9 of 13 patients showed good control of clinical symptoms. Conclusion: Intraarterial PRRT in patients with advanced meningioma is feasible and safe. It may result in improved radiologic and clinical disease control compared with intravenous PRRT. Further research to validate these initial findings and to investigate long-term outcomes is highly warranted.