PT  - JOURNAL ARTICLE
AU  - Al-Ibraheem, Akram
AU  - Abdlkadir, Ahmed
AU  - Herrmann, Ken
AU  - Bomanji, Jamshed
AU  - Jadvar, Hossein
AU  - Shi, Hongcheng
AU  - Mansour, Asem
AU  - Paez, Diana
AU  - Chiti, Arturo
AU  - Scott, Andrew M.
TI  - Diagnostic Accuracy of [<sup>18</sup>F]FDG PET/MRI in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Metaanalysis
AID  - 10.2967/jnumed.124.268049
DP  - 2024 Oct 01
TA  - Journal of Nuclear Medicine
PG  - 1533--1539
VI  - 65
IP  - 10
4099  - http://jnm.snmjournals.org/content/65/10/1533.short
4100  - http://jnm.snmjournals.org/content/65/10/1533.full
SO  - J Nucl Med2024 Oct 01; 65
AB  - This study evaluates the diagnostic utility of PET/MRI for primary, locoregional, and nodal head and neck squamous cell carcinoma (HNSCC) through systematic review and metaanalysis. Methods: A systematic search was conducted using PubMed and Scopus to identify studies on the diagnostic accuracy of PET/MRI for HNSCC. The search included specific terms and excluded nonhybrid PET/MRI studies, and those with a sample size of fewer than 10 patients were excluded. Results: In total, 15 studies encompassing 638 patients were found addressing the diagnostic test accuracy for PET/MRI within the chosen subject domain. Squamous cell carcinoma of the nasopharynx was the most observed HNSCC subtype (n = 198). The metaanalysis included 12 studies, with pooled sensitivity and specificity values of 93% and 95% per patient for primary disease evaluation, 93% and 96% for locoregional evaluation, and 89% and 98% per lesion for nodal disease detection, respectively. An examination of a subset of studies comparing PET/MRI against PET/CT or MRI alone for evaluating nodal and locoregional HNSCC found that PET/MRI may offer slightly higher accuracy than other modalities. However, this difference was not statistically significant. Conclusion: PET/MRI has excellent potential for identifying primary, locoregional, and nodal HNSCC.