RT Journal Article
SR Electronic
T1 Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [<sup>11</sup>C]UCB-J PET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP jnumed.124.267419
DO 10.2967/jnumed.124.267419
A1 Young, Juan J.
A1 O’Dell, Ryan S.
A1 Naganawa, Mika
A1 Toyonaga, Takuya
A1 Chen, Ming-Kai
A1 Nabulsi, Nabeel B.
A1 Huang, Yiyun
A1 Cooper, Emma
A1 Miller, Alyssa
A1 Lam, Jessica
A1 Bates, Kara
A1 Ruan, Audrey
A1 Nelsen, Kimberly
A1 Salardini, Elaheh
A1 Carson, Richard E.
A1 van Dyck, Christopher H.
A1 Mecca, Adam P.
YR 2024
UL http://jnm.snmjournals.org/content/early/2024/09/19/jnumed.124.267419.abstract
AB Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [11C]UCB-J PET. Methods: Participants included 31 older adults with AD and 16 with normal cognition. The distribution volume ratio (DVR) using simplified reference tissue model 2 was compared with SUVR at short scan windows using a whole-cerebellum reference region. Results: Synaptic density was reduced in AD participants using DVR or SUVR. SUVR using later scan windows (60–90 or 70–90 min) was minimally biased, with the strongest correlation with DVR. Effect sizes using SUVR at these late time windows were minimally reduced compared with effect sizes with DVR. Conclusion: A simplified tissue-to-reference method may be useful for multicenter and longitudinal studies seeking to measure synaptic density in AD.