RT Journal Article
SR Electronic
T1 Interreader and Intrareader Reproducibility of <sup>18</sup>F-Flotufolastat Image Interpretation in Patients with Newly Diagnosed or Recurrent Prostate Cancer: Data from Two Phase 3 Prospective Multicenter Studies
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1239
OP 1243
DO 10.2967/jnumed.123.267306
VO 65
IS 8
A1 Kuo, Phillip H.
A1 Esposito, Giuseppe
A1 Ulaner, Gary A.
A1 Yoo, Don
A1 Zukotynski, Katherine
A1 Ravizzini, Gregory C.
A1 Penny, Ross
A1 Miller, Matthew P.
A1 Chau, Albert
A1 Davis, Phillip
A1 Chapin, Brian F.
A1 Schuster, David M.
A1 on behalf of the SPOTLIGHT and LIGHTHOUSE study groups
YR 2024
UL http://jnm.snmjournals.org/content/65/8/1239.abstract
AB Interreader and intrareader reproducibility of 18F-flotufolastat PET/CT scans in newly diagnosed and recurrent prostate cancer patients was assessed from masked image evaluations from two phase 3 studies. Methods: 18F-flotufolastat PET/CT images of newly diagnosed (n = 352) or recurrent (n = 389) patients were evaluated by 3 masked readers. Cohen κ was used to assess pairwise patient- and region-level interreader agreement. Agreement among all readers was assessed using Fleiss κ. Intrareader agreement between the first and repeat read (20% of images, ≥4 wk later) was assessed using Cohen κ. Results: Pairwise interreader agreement was 95% or better (newly diagnosed) and 75% or better (recurrent). The κ coefficients were impacted by the high-agreement–low-κ paradox: Cohen κ ranged from not estimable to 0.55, whereas Fleiss κ was 0.50 (newly diagnosed) and 0.41 (recurrent). Agreement was highest in the prostate of newly diagnosed patients (≥95%) and in the pelvic lymph nodes in recurrent patients (≥87%). Intrareader agreement was 86% or better across both populations. Conclusion: 18F-flotufolastat PET/CT images can be reliably interpreted, with a high degree of inter- and intrareader agreement.