RT Journal Article SR Electronic T1 Dose–Response Relationship in Patients with Liver Metastases from Neuroendocrine Neoplasms Undergoing Radioembolization with 90Y Glass Microspheres JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1175 OP 1180 DO 10.2967/jnumed.124.267774 VO 65 IS 8 A1 Watanabe, Masao A1 Leyser, Stephan A1 Theysohn, Jens A1 Schaarschmidt, Benedikt A1 Ludwig, Johannes A1 Fendler, Wolfgang P. A1 Moraitis, Alexandros A1 Lahner, Harald A1 Mathew, Annie A1 Herrmann, Ken A1 Weber, Manuel YR 2024 UL http://jnm.snmjournals.org/content/65/8/1175.abstract AB The benefit of multicompartment dosimetry in the radioembolization of neuroendocrine neoplasms is not firmly established. We retrospectively assessed its potential with patient outcome. Methods: Forty-three patients were eligible. The association of mean absorbed dose (MAD) for tumors and treatment response was tested per lesion with a receiver operating characteristic curve analysis, and the association of MAD with progression-free survival (PFS) and overall survival was tested per patient using uni- and multivariate Cox regression analyses. Results: The area under the curve for treatment response based on MAD was 0.79 (cutoff, 196.6 Gy; P < 0.0001). For global PFS, grade (grade 2 vs. 1: hazard ratio [HR], 2.51; P = 0.042; grade 3 vs. 1: HR, 62.44; P < 0.001), tumor origin (HR, 6.58; P < 0.001), and MAD (HR, 0.998; P = 0.003) were significant. For overall survival, no prognostic parameters were significant. Conclusion: In line with prior publications, a MAD of more than 200 Gy seemed to favor treatment response. MAD was also associated with PFS and may be of interest for radioembolization planning for neuroendocrine neoplasm patients.