PT - JOURNAL ARTICLE AU - Singh, Amit TI - <strong>"A comparison between 99mTc TRODAT SPECT findings in Early versus Late Onset Parkinsonism"</strong> DP - 2024 Jun 01 TA - Journal of Nuclear Medicine PG - 242570--242570 VI - 65 IP - supplement 2 4099 - http://jnm.snmjournals.org/content/65/supplement_2/242570.short 4100 - http://jnm.snmjournals.org/content/65/supplement_2/242570.full SO - J Nucl Med2024 Jun 01; 65 AB - 242570 Introduction: To compare the degree and extent of presynaptic dopaminergic dysfunction in early versus late-onset Parkinsonism.Methods: Retrospectively we studied sixteen patients with parkinsonism, of which six under 50 years of age were classified as having early-onset parkinsonism and the remaining ten patients over the age of 50 years were classified as having late-onset parkinsonism.Results: We found a direct correlation between the severity &amp; duration of symptoms with the degree &amp; extent of presynaptic dopaminergic dysfunction in early and late-onset Parkinsonism. On visual and semiquantitative analysis, no significant difference was noted in the degree of presynaptic dopaminergic dysfunction in the early and late-onset parkinsonism group. In both groups, caudate nuclei were less (37.5%) frequently involved (early 30.0%, late 45.0%) however putamen nuclei were more (71.9%) frequently and severely involved (early 66.7%, late 75.0%). The p-value for caudate vs putamen in total patients was significant (p-value 0 .005742). Conclusions: Our (SPECT-TRODAT) result showed no significant difference in the degree and extent of presynaptic dopaminergic dysfunction in early and late-onset Parkinsonism.